Detecting cancer with a blood test: New study shows promise, but questions remain

A study published this week in Science reports promising results of a blood test designed to detect eight common cancer types by measuring circulating proteins and mutations in cell-free DNA. The study comes from the Johns Hopkins Kimmel Cancer Center at Johns Hopkins and has created a lot of buzz. We asked J. Leonard Lichtenfeld, M.D., MACP, deputy chief medical officer to share his thoughts about the study.

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Len Lichtenfeld, M.D.

“The study reported this week on the potential of cell free DNA providing another option for the early detection of cancer represents elegant science. It is one more step down what we expect to be a long path of discovery to determine if this approach is not only effective at early detection but, far more important, also improves outcomes for those diagnosed with cancer.

“The test is one of several approaches with a similar focus on the early detection of cancer. Which tests will achieve this goal is not certain at this time.

“It is important to remember that it is one thing to advance the science and the technology; however it is something entirely different to demonstrate that the test will actually make a difference in saving lives. Notwithstanding the results of this study in patients who have already been diagnosed with cancer, it is possible that we may find that the test will find cancers early and we won’t be able to accurately determine where the cancer came from. Or we may learn that simply find these cancers early may not make treatment more effective or impact lives to the degree we had hoped for. These are answers we need.

“In simpler terms:  we have a long way to go to demonstrate the utility and value of this test. We cannot make assumptions regarding the ability of this test to detect cancer early based on this study. We need additional research (which is being undertaken) to prove that it is possible to find cancer signals in the blood of patients before it is otherwise known they have cancers. Those studies are moving forward at this time.

“We have made assumptions in the past about the ability of blood tests to diagnose cancer early with—for example–tests for prostate and colon cancers. The prostate cancer experience should teach us that we need to prove value and utility before we again subject potentially millions of people to possibly unnecessary medical procedures and treatment which ultimately have not necessarily improved the length or the quality of their years.”

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Study links inflammation-causing foods to higher risk of colorectal cancer

A study in today’s JAMA Oncology links diets that include foods that can cause inflammation to an increased risk of colorectal cancer.  Those foods include meats, refined grains, and high-calorie beverages. We asked Marji McCullough, SCD, RD, strategic director of nutritional epidemiology at the ACS.

JAMA Onc“There has been a lot of interest in the role of diet in inflammation, and in fact several anti-inflammatory diets have begun to be promoted. This is an observational study, not interventional, so it has some limitations, but it does shed some light on the issue.

“There are several ways diet may influence colorectal cancer risk, including inhibiting or promoting inflammation, which is the focus of this paper. Chronic inflammation can cause DNA damage and lead to unregulated cell growth. Other ways diet could influence colorectal cancer risk is through antioxidant effects (protecting against DNA damage), influencing the cell cycle, and direct consumption of carcinogens.

“While it’s tempting to focus on specific foods, how overall diet contributes to this inflammatory effect is likely more important than individual foods because foods may act together in influencing disease risk.

“It’s possible the impact of diet is even greater than that measured in the current study, which captured only some of the foods that are likely to influence inflammation. For example, certain spices and food preparation methods that were not included may have strong effects on inflammation.

“It’s interesting to consider that what you eat may be just as important as what you don’t. In other words, many foods and beverages are substitutions for each other. One strength of this paper is that it takes the total diet into account.

“Another important aspect of this study is that it focused on foods, not supplements. It underscores how food can have significant roles in influencing disease risk.

“As far as what people should know about colorectal cancer and diet: The International Agency for Research on Cancer (IARC) determined that processed meat is a carcinogen, and red meat is a probable carcinogen, so lower intakes of both would reduce colorectal cancer risk. Whole grains and (low fat) dairy foods are associated with lower risk of colorectal cancer. Whole grains add bulk to the diet and may dilute carcinogens. Whole grains and other plant foods also contribute to beneficial microbiome diversity. Dairy foods contain calcium and vitamin D, which have beneficial effects on cell proliferation and differentiation.

“The bottom line: It’s important to consider the total diet, as a combination of lots of healthy foods and lower amounts of unhealthy foods are likely to have additive and synergistic effects on lowering cancer risk.”

 

Posted in Colorectal, Nutrition, Research, Uncategorized | Tagged , | 1 Comment

Behind the numbers: cancers associated with obesity

A report out today had a lot of us scratching our heads, when it said that about 630,000 people in the U.S. were diagnosed with a cancer associated with overweight and obesity in 2014.

That sounds awfully high, we thought.

It went on to say more than half, 55 percent of all cancers diagnosed in women and about one in four, 24 percent of those diagnosed in men are associated with overweight and obesity.

Now you got our attention.

We asked Farhad Islami, MD PhD, strategic director of cancer surveillance research to have a look. And it turns out there was a simple, and important explanation.

“It’s important to note that only a fraction of the cancers included in the calculation in this report are actually caused by excess body weight. For this study, the authors totaled all of the cancers diagnosed in 2014 for 13 types that have been linked to some extent with excess body weight. In other words, the reported number, 631,000 cancer cases representing 40% of all cancers diagnosed, represents all cases among those 13 types, even though not all of those cancers are caused by excess body weight. Many are attributable to other known risk factors, like smoking, while for many others, the cause is unknown. Obesity is more strongly associated with some cancers than others.

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Farhad Islami, M.D., Ph.D.

“As far as the actual estimate of the percentage of all cancers associated with obesity: The World Cancer Research Fund estimates that 20% of all cancers in the United States are caused by a combination of excess body weight, physical inactivity, excess alcohol, and poor nutrition. The American Cancer Society is currently doing its own extensive calculation of the numbers and proportions of cancer cases attributable to excess body weight, the results of which will be published soon.”

Update: Two days later, several headlines confirm this effort to highlight a real problem led to widespread misreporting obesity headlines

 

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New Analysis Confirms Suspected Bias of Large U.S. Prostate Screening Study

A new paper appearing in Annals of Internal Medicine used simulation modeling to try to correct for a known bias in a notable U.S. trial of prostate cancer screening, called PLCO. That study along with a large European one played an important role in the creation of screening guidelines from the American Cancer Society and others.

While the major European trial, called ERSPC, suggested routine PSA screening reduced the risk of prostate cancer death by about 30 percent in men who were very compliant with screening and treatment, the U.S. study failed to show a benefit. The U.S. trial is widely-believed to have been contaminated; many men in the control arm, who were assumed to be unscreened, were in fact screened thanks to the wide availability of PSA testing at the time, diminishing the differences between the studies two arms.

We asked Chief Medical Officer Otis W. Brawley, M.D. if the new data changes the current understanding of PSA screening.

“This new analysis supports the widespread understanding that PSA screening under optimal conditions has larger mortality benefits than were shown by a large U.S. trial. It also supports a move towards watchful waiting that all experts hope will make screening as useful as possible.

“The new analysis uses a measure known as ‘mean lead time’ to try to account for suspected biases in the U.S.-based PLCO trial. Some consider this modeling controversial and unproven. Nonetheless, it may be useful in this situation.

“The findings from the new analysis are consistent with the assessments of most experts, who generally agree that prostate cancer screening is associated with a reduction in prostate cancer deaths, and that the U.S. trial undercounted this benefit.

“Screening recommendations from the American Cancer Society and others have acknowledged the limitation of the U.S. trial, so this new analysis does not significantly change the body of evidence on which our recommendations are based.

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Otis W. Brawley, M.D., MACP

“A reduction in the risk of death is only half the equation when weighing whether to recommend screening. Guidelines from the ACS and others must weigh those benefits against some fairly serious side effects associated with screening and its subsequent treatment. The question is whether the benefit of widespread routine screening outweighs the risks of harm.

“The ACS was one of the first of many organizations that now recommend informed or shared decision making regarding prostate cancer screening, based on the fact that the potential benefits of screening can be offset by harms associated with the large number men who would be treated.

“Most organizations including the ACS now agree men in their 50s should be informed by their clinician regarding the potential benefits and risks of screening. This analysis will not change that recommendation. 

“Prostate cancer screening has been an area in need of clarity. This study validates the findings from the two major studies that prostate cancer screening does save lives.

“Those two studies also showed that many men diagnosed with prostate cancer through screening are candidates for observation rather than immediate, aggressive therapy.

“This approach, called watchful waiting, has lessened the harms associated with detecting prostate cancer through screening and has begun to change the risk benefit ratio.

“It is hoped that continuing the trend toward carefully selecting which men get screened for prostate cancer, developing better methods for distinguishing low and high risk prostate cancers, and carefully monitoring those who are found to have low risk cancer has the potential to optimize PSA screening to leverage its lifesaving potential while reducing harms of unnecessary treatment.”

For more information, see Can Prostate Cancer Be Found Early? on cancer.org.

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Don’t Fry Day: Getting Sunscreen Right

Despite increased awareness about the dangers of ultraviolet (UV) radiation, melanoma rates continue to rise in the United States. For “Don’t Fry Day” on May 26, the American Cancer Society is cautioning that many people may be using sunscreen improperly, not only limiting its effectiveness but potentially increasing their risk of skin cancer.

melanomaData from the CDC’s Surveillance, Epidemiology, and End Results (SEER) program show rates of new melanoma cases have been rising for three decades, and on average 1.4% each year over the last 10 years. The rise comes despite heightened awareness about the dangers of UV radiation as well as widespread promotion of the use of sunscreen.

“Our fear is people are not using sunscreen correctly, and even when they do, many are using it inappropriately,” said Richard C. Wender, M.D., chief cancer control officer of the American Cancer Society. “People may be using sunscreen to go out in the sun in the middle of the day, when the risk is highest, and to stay out longer. Adding to the problem is the fact that many people do not use enough sunscreen and do not re-apply frequently enough.”

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Richard C. Wender, M.D.

“People primarily worry about sunburn, which is understandable. Severe sunburns are an important risk factor for melanoma. But sunburn only tells you how much UVB radiation exposure you’ve had; it tells you very little about how much exposure you’ve had to UVA radiation,” said Dr. Wender.

While UVB is the chief culprit behind sunburn, UVA rays penetrate the skin more deeply, are associated with wrinkling, leathering, sagging, and other light-induced effects of aging. UVA rays also exacerbate the carcinogenic effects of UVB rays, and increasingly are being seen as a cause of skin cancer on their own.

Sunscreens vary in their ability to protect against UVA and UVB. Sun Protection Factor or SPF measures how effectively the sunscreen formula limits skin exposure to UVB rays that burn the skin. SPF does not measure UVA. Only “broad spectrum” sunscreens protect against both UVA and UVB.

“Sunscreens are important, no doubt,” says Dr. Wender. “But they should not be a first line of defense against the sun. The first line should be avoiding midday sun.”

The American Cancer Society recommends:

  • Seek shade Avoid being outdoors in direct sunlight too long between the hours of 10 am and 4 pm, when UV light is strongest.
  • Protect your skin with clothing: When you are out in the sun, wear clothing to cover your skin. Long-sleeved shirts, long pants, or long skirts cover the most skin and are the most protective. A tightly woven fabric protects better than loosely woven clothing. If you can see light through a fabric, UV rays can get through, too.
  • Wear a hat: A hat with at least a 2- to 3-inch brim all around is ideal because it protects areas that are often exposed to intense sun, such as the ears, eyes, forehead, nose, and scalp.
  • Wear sunglasses that block UV rays
  • Use sunscreen: Use an SPF 30 or higher broad spectrum sunscreen. Ideally, about 1 ounce, about a shot glass or palmful, should be used to cover the arms, legs, neck, and face of the average adult. Sunscreen needs to be reapplied at least every 2 hours to maintain protection.

While sunscreens with SPF above 50 are available, Dr. Wender says they offer little additional protection, and could backfire if people overestimate the additional protection they provide.

“SPF 30 sunscreens filter out about 97% of the sun’s UVB rays. SPF 50 brings that to about 98%, and SPF 100 to about 99%. So the higher you go, the smaller the difference becomes. And that number says nothing about UVA rays,” said Dr. Wender. “People may see the higher number, overestimate its ability to block additional rays, and increase their exposure and their risk. That’s why your first line of defense must be avoiding the bright sun in the middle of the day.”

The National Council on Skin Cancer Prevention (NCSCP www.skincancerprevention.org) designated the Friday before Memorial Day as “Don’t Fry Day,” a public awareness campaign that promotes sun safety and encourages people to protect their skin while enjoying the outdoors. Core members of NCSCP include the American Cancer Society, the American Academy of Dermatology, the Melanoma Research Foundation, and the Skin Cancer Foundation.

For more information, see: Skin Cancer Prevention and Early Detection on cancer.org.

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Ventilated Filters: Changing the Face of Lung Cancer in the U.S.

LungCawithPICCAn analysis appearing in the Journal of the National Cancer Institute finds strong evidence that adding ventilation holes to cigarette filters has contributed to a rise in a type of lung cancer called adenocarcinoma among smokers. The authors say the FDA should consider regulating the use of filter ventilation, up to and including a ban.

Eric Jacobs, Ph.D., strategic director of pharmacoepidemiology says the new analysis is a welcome addition to existing information about the dangers of ventilated cigarette filters and should lead to further research to find out whether regulation is warranted.

“Rates of lung cancer in cigarette smokers were already high in the 1950s and 1960s, but have increased over time, driven by increases in adenocarcinoma, now the most common type of lung cancer. The new review in the Journal of the National Cancer Institute is therefore important because it systematically lays out and evaluates the scientific evidence that a specific change in cigarette design, the introduction of filter ventilation holes, may be responsible for the increased risk of adenocarcinoma of the lung in smokers.

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Eric M. Jacobs. Ph.D.

“Ventilation holes, engineered into cigarette filters by the tobacco industry starting in the 1960s, are present in nearly all modern cigarettes and are tied to a long history of deception. These holes allow air to be drawn in, resulting in cigarettes that have lower tar levels when measured by smoke-testing machines and that have been misleadingly marketed as “light” or “low-tar.” In fact, it has long been known that real-life smokers inhale similar amounts of tar when smoking cigarettes with ventilation holes. This occurs because smokers, often unconsciously, compensate for the ventilation holes by changing their smoking behavior, for example by taking by taking bigger puffs, in order to obtain the level of nicotine to which they are addicted.

“Among other evidence, the review describes studies showing that ventilation holes cause smokers to take bigger puffs, potentially inhaling carcinogen-containing smoke deeper into the parts of the lungs where adenocarcinoma typically arises.

“Thorough evidence reviews, like this one, help establish the scientific basis the Food and Drug Administration (FDA) needs to make sound decisions about the regulation of ventilation holes and other design features of tobacco products.”

Posted in Behavior, Environment, Lifestyle, Lung, Prevention, Research, Tobacco | 1 Comment

14: The Unmentioned Number in the Prostate Cancer/Coffee Story

CoffeeHeadlines across the Internet blared with the news over the past week that coffee could cut the risk of prostate cancer in half.  It was an irresistible headline. But just how reliable was the finding?

What if I told you it was based on just over a dozen cancer cases.

You read that right. All those headlines leaping out at you, based on 14 prostate cancers among heavy coffee drinkers.

To get some perspective on this, we turned to Eric Jacobs, Ph.D., Strategic Director of  Pharmacoepidemiology for the American Cancer Society. Here’s what he told us.

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Eric M. Jacobs. Ph.D.

“While the 53% reduction in risk of prostate cancer in Italian men drinking more than 3 cups a day observed in this study is certainly eye-catching, it need to be interpreted cautiously.

“First, while the study design is generally sound, it is an observational study, not a randomized trial.  Second, it is based on small numbers, only 14 prostate cancer cases in men drinking more than 3 cups a day, so the amount of impact on prostate cancer risk, if any, is very uncertain.

“Third, this is one of many studies of coffee and prostate cancer. Previous studies have had mixed results, a meta-analysis of 9 previous cohort studies found about 10% lower risk of prostate cancer in men drinking moderate to high amounts of coffee, indicating that coffee drinking is unlikely to have a large effect on risk of prostate cancer.

The bottom line: there is not convincing evidence that coffee lowers risk of prostate cancer.”

So enjoy your coffee with your morning news reading. Just don’t rely on it to do much more than give your day a jump start.

Learn more about prostate cancer here.

Posted in Behavior, Communications, Nutrition, Prevention, Prostate | Tagged , , , , , , | Leave a comment